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The third and most well known of the toxic metabolites of yeast is acetyl aldehyde

doi: 10.1038/s41423-018-0027-x 88 ChatilaTA

VSMCs were cultured in 12-well plates for 48 h

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19,20 With aging, mitochondrial function declines, leading to decreased energy metabolism, increased ROS production, and the accumulation of mtDNA mutations, alongside the deterioration of other mitochondrial functions